5. Capsaicin Cream

Capsaicin is the compound that gives chili peppers their heat. When used in topical creams, it works by depleting substance P, a neurotransmitter involved in transmitting pain signals to the brain. With repeated use, this leads to a temporary reduction in local pain sensitivity.
For psoriatic arthritis, capsaicin cream can offer targeted relief for joint discomfort. It is particularly useful for superficial joints like fingers, knees, or elbows where the cream can penetrate close to the site of inflammation. This treatment does not affect the underlying disease but helps manage pain effectively.
The cream is usually applied three to four times a day. It may cause a warm or burning sensation on the skin initially, but this effect lessens with regular use. Washing hands thoroughly after application is important, and care should be taken to avoid contact with eyes or mucous membranes.
Studies suggest that capsaicin is safe for long-term use when applied properly. It is available over the counter in strengths ranging from 0.025 to 0.1 percent. Stronger formulations may require a prescription.
In addition to reducing joint pain, some people find it helps with the skin discomfort associated with psoriasis. However, it should never be applied to broken or irritated skin. Capsaicin cream can be a helpful option for people seeking non-systemic relief with minimal side effects.
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